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The Benefits of UV Light Read and discuss all the great news about UV light and Vitamin D.

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Old 10-25-2006, 10:54 PM   #1 (permalink)
 
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Most Vitamin D Pills in the USA aren't the same as what UV helps with.

There is a difference between most pill forms of vitamin D. I often have people tell me well my Dr. told me to a take a multi-vitamin for my vitamin D. This type of vitamin D is vitamin D2. Vitamin D2 was created for rickets long ago, it does not have the same health benefits as vitamin D3. There is a company called cytochroma that seems to have a lead on the D3 combination. Anyway this is just to let you know a little bit about the differences....our tanning beds put off the important vitamin D3 just like the sun does. Here is a link to the American Journal of Clinical Nutrition that is more technical!

http://www.ajcn.org/cgi/content/abstract/84/4/694
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Old 10-26-2006, 06:30 AM   #2 (permalink)
 
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Re: Most Vitamin D Pills in the USA aren't the same as what UV helps with.

http://www.vivo.colostate.edu/hbooks.../vitamind.html

Bioactive vitamin D or calcitriol is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. More recently, it has become clear that receptors for vitamin D are present in a wide variety of cells, and that this hormone has biologic effects which extend far beyond control of mineral metabolism.
Structure and Synthesis

The term vitamin D is, unfortunately, an imprecise term referring to one or more members of a group of steroid molecules. Vitamin D3, also known as cholecalciferol is generated in the skin of animals when light energy is absorbed by a precursor molecule 7-dehydrocholesterol. Vitamin D is thus not a true vitamin, because individuals with adequate exposure to sunlight do not require dietary supplementation. There are dietary sources of vitamin D, including egg yolk, fish oil and a number of plants. The plant form of vitamin D is called vitamin D2 or ergosterol. However, natural diets typically do not contain adequate quantities of vitamin D, and exposure to sunlight or consumption of foodstuffs purposefully supplemented with vitamin D are necessary to prevent deficiencies.
Vitamin D, as either D3 or D2, does not have significant biological activity. Rather, it must be metabolized within the body to the hormonally-active form known as 1,25-dihydroxycholecalciferol. This transformation occurs in two steps, as depicted in the diagram to the right:
  1. Within the liver, cholecalciferal is hydroxylated to 25-hydroxycholecalciferol by the enzyme 25-hydroxylase.
  2. Within the kidney, 25-hydroxycholecalciferol serves as a substrate for 1-alpha-hydroxylase, yielding 1,25-dihydroxycholecalciferol, the biologically active form.
Each of the forms of vitamin D is hydrophobic, and is transported in blood bound to carrier proteins. The major carrier is called, appropriately, vitamin D-binding protein. The halflife of 25-hydroxycholecalciferol is several weeks, while that of 1,25-dihydroxycholecalciferol is only a few hours.
Control of Vitamin D Synthesis

Hepatic synthesis of 25-hydroxycholecalciferol is only loosely regulated, and blood levels of this molecule largely reflect the amount of amount of vitamin D produced in the skin or ingested. In contrast, the activity of 1-alpha-hydroxylase in the kidney is tightly regulated and serves as the major control point in production of the active hormone. The major inducer of 1-alpha-hydroxylase is parathyroid hormone; it is also induced by low blood levels of phosphate.
The Vitamin D Receptor and Mechanism of Action

The active form of vitamin D binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. The vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription.
The vitamin D receptor binds several forms of cholecalciferol. Its affinity for 1,25-dihydroxycholecalciferol is roughly 1000 times that for 25-hydroxycholecalciferol, which explains their relative biological potencies.
Physiological Effects of Vitamin D

Vitamin D is well known as a hormone involved in mineral metabolism and bone growth. Its most dramatic effect is to facilitate intestinal absorption of calcium, although it also stimulates absorption of phosphate and magnesium ions. In the absence of vitamin D, dietary calcium is not absorbed at all efficiently. Vitamin D stimulates the expression of a number of proteins involved in transporting calcium from the lumen of the intestine, across the epithelial cells and into blood. The best-studied of these calcium transporters is calbindin, an intracellular protein that ferries calcium across the intestinal epithelial cell.
Numerous effects of vitamin D on bone have been demonstrated. As a transcriptional regulator of bone matrix proteins, it induces the expression of osteocalcin and suppresses synthesis of type I collagen. In cell cultures, vitamin D stimulates differentiation of osteoclasts. However, studies of humans and animals with vitamin D deficiency or mutations in the vitamin D receptor suggest that these effects are perhaps not of major physiologic importance, and that the crutial effect of vitamin D on bone is to provide the proper balance of calcium and phosphorus to support mineralization.
It turns out that vitamin D receptors are present in most if not all cells in the body. Additionally, experiments using cultured cells have demonstrated that vitamin D has potent effects on the growth and differentiation of many types of cells. These findings suggest that vitamin D has physiologic effects much broader that a role in mineral homeostasis and bone function. This is an active area of research and a much better understanding of this area will likely be available in the near future.
Disease States

Vitamin D deficiency: The classical manifestations of vitamin D deficiency is rickets, which is seen in children and results in bony deformaties including bowed long bones. Deficiency in adults leads to the disease osteomalacia. Both rickets and osteomalacia reflect impaired mineralization of newly synthesized bone matrix, and usually result from a combination of inadequate exposure to sunlight and decreased dietary intake of vitamin D.
Vitamin D deficiency or insufficiency occurs in several other situations, which you might predict based on the synthetic pathway described above:
Genetic defects in the vitamin D receptor: a number of different mutations have been identified in humans that lead to hereditary vitamin D resistance.
Severe liver or kidney disease: this can interfere with generation of the biologically-active form of vitamin D.
Insufficient exposure to sunlight: Elderly people that stay inside and have poor diets often have at least subclinical deficiency. Ironically, it appears that hypovitaminosis D is very common in some of the most sunny countries in the world - the cause of this problem is the cultural dictate that women be heavily veiled when outside in public.
Sunscreens, especially those with SPF ratings greater than 8, effectively block synthesis of vitamin D in the skin. However, people that use such sunscreens religiously live in industrial countries where many foods are supplemented with vitamin D, and vitamin D deficiency is thereby averted by dietary intake.
Vitamin D toxicity: Excessive exposure to sunlight does not lead to overproduction of vitamin D. Vitamin D toxicity is inevitably the result of overdosing on vitamin D supplements. Don't do this! Ingestion of milligram quantities of vitamin D over periods of weeks of months can be severely toxic to humans and animals. In fact, baits laced with vitamin D are used very effectively as rodenticides.
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Old 10-26-2006, 09:18 AM   #3 (permalink)
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Re: Most Vitamin D Pills in the USA aren't the same as what UV helps with.

Wow..GREAT info Billable..Bravo..Bravo..
Love this research.."Your my Hero"

KEEP up the great work and education...
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Old 11-05-2006, 03:41 PM   #4 (permalink)
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Re: Most Vitamin D Pills in the USA aren't the same as what UV helps with.

thank you! thank you!
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Old 11-05-2006, 05:17 PM   #5 (permalink)
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Re: Most Vitamin D Pills in the USA aren't the same as what UV helps with.

lol...so now I can use my vitamin d enhanced milk to catch mice?
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Old 10-10-2012, 12:12 AM   #6 (permalink)
 
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Re: Most Vitamin D Pills in the USA aren't the same as what UV helps with.

I'm still following this company... 6 yeas later they are entering phase III
Cytochroma
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Old 11-05-2012, 11:43 AM   #7 (permalink)
 
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Re: Most Vitamin D Pills in the USA aren't the same as what UV helps with.

Thanks Eileen. Funny, I had a physical last week, my doctor wanted to test my vitamin D levels and I brought up my regular UV exposure. She tried to tell me that it is very unlikely that you can get enough vitamin D from UV and a dietary supplement is a must because so many people are deficient these days. To prove her wrong, I ordered the test fro D3.....my levels were perfect! I do not take vitamins, I am a firm believer in sunlight, exercise and a balanced diet for health (unless there are extenuating circumstances).
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Old 11-15-2012, 12:33 AM   #8 (permalink)
 
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Re: Most Vitamin D Pills in the USA aren't the same as what UV helps with.

I had the exact same experience w/my Dr. as Dilworth and proved him wrong as did my Manager. We don't take vitamins either. It's interesting how quickly they turn to supplements and are so surprised when the tests come back :)
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Old 11-15-2012, 08:04 PM   #9 (permalink)
 
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Re: Most Vitamin D Pills in the USA aren't the same as what UV helps with.

The trend in the last couple years has been more and more clients coming in for vitamin D and some being suggested from their doctors. The last month, I have had 2 clients who have said their doctors are telling them that UV will not produce vitamin D. I was shocked.

Now they aren't warning against tanning, now they are just lying?
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Old 02-02-2013, 03:25 PM   #10 (permalink)
 
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Re: Most Vitamin D Pills in the USA aren't the same as what UV helps with.

Real vit d from uv light is like having a stadium full of people, all cheering.Supplementation even if it is with d3 ,in my opinion is like having the seats full at the stadium ,but the crowd is silent.

The danger of vit d "research" is that it is most likely to all be based on supplements,so therefore the potential for major acceptance and disease prevention will be diluted.

I have a hard time believing that something that is made by the body in such a sophisticated manor can be replicated in pills.( i hate that word,pills)
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