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Old 05-19-2008, 11:27 AM   #1 (permalink)
 
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'Sunshine vitamin' aids women, study shows

'Sunshine vitamin' aids women, study shows
BY KAY QUINN
SPECIAL TO THE POST-DISPATCH
05/19/2008


Vitamin D is a hot topic in medical circles. For years, the U.S. Dietary Reference Intake has recommended 200 international units of vitamin D a day, more for pregnant women or older people. But increasingly, physicians believe higher daily doses are needed to achieve optimal health.

"We're discovering vitamin D is not just for the bone, but beyond that, vitamin D is really an immune modulator," Dr. Antonella Rastelli said.

According to epidemiological studies, Rastelli said, people with low levels of the vitamin may be more prone to breast cancer, colon cancer, and prostate cancer.

"Also there are other conditions that are associated with vitamin D deficiency or insufficiency, such as more high blood pressure, diabetes, and multiple sclerosis," Rastelli said. "We're starting to see literature tying getting older and vitamin D, and low levels being associated with aspiration pneumonias, trouble swallowing, urinary incontinence."


Vitamin D is called the sunshine vitamin because the body makes it following sun exposure. The vitamin can also come from food sources, such as fish and fortified milk. But often, people don't get enough through sunshine and diet alone.

That makes supplementation important, according to Rastelli, who recommends 800 IU a day for adults and as much as 1,300 IU a day for older adults.

She's even carrying the idea one step further. Rastelli is the principal investigator of a study at Washington University School of Medicine. She is looking at whether vitamin D supplementation in breast cancer patients taking the drug Arimidex can lower the joint pain often associated with the medication. Arimidex is a drug that completely blocks the production of estrogen, the hormone implicated in the growth of many breast tumors.

Study participants are divided into two groups. All take calcium supplements. But half of the patients also take 50,000 IU a week for six months. Neither the participants nor Rastelli know who is getting the vitamin D.

Brenda Steinmetz, 62, of Mulkeytown, Ill., is a breast cancer survivor who enrolled in the study one year ago after Arimidex left her with arthritis-like symptoms.

"In the very beginning my feet and legs, when I would sit for any period of time, they would get very stiff," Steinmetz said.

'MORE ENERGETIC'

But she believes that she was getting a placebo in the first six months of the study because her symptoms continued even after enrolling. After completing the first six months, she was offered the vitamin D supplement.

"Within a week or less I could tell, I was more energetic," Steinmetz said. "I know that it has helped me and made me feel better."

Rastelli says she needs a few more volunteers before being able to prove scientifically that vitamin D works to alleviate pain associated with Arimidex. "Anecdotally we've seen a lot of improvement" in patients getting the supplements.

Candidates are women diagnosed with breast cancer who are taking Arimidex and experiencing joint pain.

Risks associated with the study are low, according to Rastelli.

"Vitamin D is a very, very safe vitamin. The only thing that can happen sometimes is it increases the absorption of calcium. So patients taking too much calcium along with vitamin D, may be at a slight increased risk for kidney stones," Rastelli said.

If you would like more information about the study, call 314-362-1000 or 1-866-362-5656.

Kay Quinn is a reporter and anchorwoman at KSDK (Channel 5).

SOURCE LINK: http://www.stltoday.com/stltoday/lif...2?OpenDocument
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