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Old 02-24-2008, 12:50 AM   #1 (permalink)
 
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Vitamin D may lessen the pain for those on Arimidex/Breast Cancer

Another nice find......


Life with Breast Cancer
by Kathy-Ellen Kups
A personal take on breast cancer
February 23, 2007
Vitamin D may lessen the pain for those on Arimidex My concerns regarding Arimidex (anastrozole) have not lessened. Several blogs ago, I told you that I would contact the makers of Arimidex and find out where the bone pain comes from. I am not getting any satisfactory answers, but, AstraZeneca (the company who makes the drug) is aware of reports of bone pain. They are aware enough to provide funding for a study concerning ways to alleviate it.In March 2006, a press release in “Medical News” from the Washington University in St. Louis announced that AstraZeneca was providing funding for a new study to determine the effects of vitamin D on musculoskeletal pain, since some women who have taken vitamin D supplements have reported that the pain is lessened and in some instances goes away completely. Turns out, women who take Arimidex are found to have low levels of vitamin D in their blood.Two Washington University physicians, Dr. Antonella Rastelli and Marie Taylor, M.D. are conducting a double blind, placebo-controlled study to determine just how effective vitamin D supplements are on joint, muscle and bone pain caused by Arimidex. These physicians noticed the positive effects of vitamin D on patients they were treating with Arimidex and hope to substantiate evidence through a clinical trial.The theory behind the study is that Arimidex interferes with enzymes in the liver that process vitamin D and therefore vitamin D stores are depleted. Most people’s diets are lacking in this important nutrient as it comes mainly from whole milk, liver and fatty fish. It is also produced in the skin as a reaction to sun. Ironically, most cancer patients, and those wanting to decrease cancer risk avoid dairy products and organ meats while the mercury threat reduces the intake of fatty fish. In addition, with all of the concern over skin cancers, people are avoiding the sun and using sunscreen. There goes the vitamin D, and if you are not aware of the requirements while on Arimidex, then you end up in great pain and experiencing bone depletion.
Just how important is vitamin D? Well, it supports immune function, helps to regulate blood pressure, insulin levels in the blood and affects cell growth. Pretty important, eh? (hey, I’m Canadian) Vitamin D is crucial in bone health as it aids in the absorption of calcium. This is something to discuss with your doctor. It is important to determine the amount of the supplement and ensure he or she is aware that you are taking it. Most doctors are advising patients to take calcium supplements, and vitamin D is now being added to most of these supplements. For those of you suffering from intense pain while on Arimidex, this is groundbreaking news!
-Kathy-Ellen

SOURCE LINK: http://blog.healthtalk.com/breast-ca...e-on-arimidex/
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Old 02-24-2008, 10:48 AM   #2 (permalink)
 
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Re: Vitamin D may lessen the pain for those on Arimidex/Breast Cancer

Also, a recent study showed that women (and men) with breast cancer that are in the highest quintile of vitamin D (25-OH-D) have a better survival rate (>70%) than the women (and men) in the lowest quintile.

So attaining/maintaining an optimal level (>120 nmol/L) of vitamin D helps to prevent breast cancer; increases survival time for those who have breast cancer; and reduces bone pain for those being treated (as shown above) for breast cancer with Arimidex. If this win-win-win information isn't enough to cause all "smart" women to head for their local tanning salon, I don't know what is.

BTW, a new study by Liu (Holick's group), et al, showed that there is a 1% increase in vitamin D for every minute spent in a tanning bed for the first five weeks (three sessions per week) and then it levels off. The "increase" was 150% from "baseline" which means that someone with a 50 nmol/L level would increase to 125 nmol/L during these 15 sessions. Yes, you read this correctly. The study WAS done in a tanning bed (i.e., the 100w Tan America and Puretan sunbeds that I got Peter & Julie Demetroulas (Tan America) and Roger Brown (Puretan) to donate to Dr. Holick a few years ago). The last I heard, Wolff and Cosmedico sunlamps were being used. The study (in the March, 2008 issue of the Journal of Bone and Mineral Research) concludes that "Exposure to lamps taht emit UVB is an excellent source for producing vitamin D3 in the skin and is especially efficacious in patients with fat malabsorption syndrome."
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Old 02-24-2008, 10:42 PM   #3 (permalink)
 
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Re: Vitamin D may lessen the pain for those on Arimidex/Breast Cancer

Thank you Don, my sister has been working at astra-zeneca (previously ici) for 27 years. I'm going to see if she can get me any more information or updates.
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Old 03-12-2008, 10:47 AM   #4 (permalink)
 
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Re: Vitamin D may lessen the pain for those on Arimidex/Breast Cancer

Eileen was just wondering if your sister was able to get anymore info on this for us to use????


It's such a great article to share!!
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Old 07-18-2008, 01:53 PM   #5 (permalink)
 
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Re: Vitamin D may lessen the pain for those on Arimidex/Breast Cancer

Hi-I just became familiar with this issue myself, so I'm glad to see others raising awareness. I was dx'ed last August, took Arimidex for 6 months without a twinge of pain. Then all **** broke loose with crushing, throbbing, body-wide pain. I was switched to several other AIs, then back to Armidex, on and off it 3 times since April. Turns out my vitamin D level (I have an excellent integrative onc.) had plummeted from mid 50's to 32 while taking 5000 IU vitamin D daily(not a misprint!). Is this responsible for the unbearable pain? I don't know. In the last 4 weeks I have been getting 30 minutes mid day sun, taking 2 TBS cod liver oil, and taking 50,000 IU capsules once a week. Don't know if my D level has gone back up yet, (doc just drew blood to test last week) but the pain was so severe I had to stop the Arimidex last week yet again.

Anyway, I was aware (and my onc agrees) that blood levels should be between 60 and 80, so I'm wondering where you got the number >120 from? Seems to me a level THAT high would be a toxic overdose, which is also dangerous and very difficult to correct. Could you provide references for attaining such a high level?

Thanks!
Maddy

*So attaining/maintaining an optimal level (>120 nmol/L) of vitamin D helps to prevent breast cancer; increases survival time for those who have breast cancer; and reduces bone pain for those being treated (as shown above) for breast cancer with Arimidex.*
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Old 07-21-2008, 11:29 PM   #6 (permalink)
 
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Re: Vitamin D may lessen the pain for those on Arimidex/Breast Cancer

Saving Grace, Dr. Holick says levels at 100 ng/ml are safe. Here's a paragraph from one of his reports:

The only way to know whether you are getting enough vitamin D is to have your doctor measure your blood for 25-hydroxyvitamin D, the circulating form. Most experts, including myself, believe that a blood level of less than 20 ng/ml indicates vitamin D deficiency. However, to obtain the full health benefits of vitamin D, I recommend maintaining a blood level of greater than 30 ng/ml. Levels of up to 100 ng/ml are safe and not associated with toxicity. However, patients who suffer from the rare disease sarcoidosis should discuss this with their doctor, since increasing blood level above 30 ng/ml can cause them to have excessively high blood calcium. For details, please visit my web site (VitaminDHealth.org), where there is a wealth of information on vitamin D.

Source Link: http://www.stopagingnow.com/news/new...iency-Epidemic
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