08-13-2007, 04:52 PM | #1 (permalink) |
Join Date: Feb 10 2005
Posts: 8,304
Rep Power: 35 | Vitamin D for treatment of scleroderma P.G. Humbert, Department of Dermatology, Centre Hospitalier Universitaire St-Jacques, 25030 Besançon Cédex, France.Summary1,25-Dihydroxyvitamin D3 [1,25(OH)2 D3] may be an immunomodulatory drug which could have a role in controlling collagen deposition, and inducing reversal of fibrosis in some tissues. These observations prompted a study of the possible use of this hormone for the treatment of scleroderma. A 35-year-old woman, who had been suffering from localized scleroderma for 2 years, was given oral 1,25(OH) 2 D3 for 6 months. The effects of the treatment were evaluated using clinical and physical measurements (skin thickness, extensibility properties of the skin). The evolution of the patient's condition during the 6-month therapy suggests that 1,25(OH)2 D3 is beneficial in localized scleroderma. The mechanisms of action are discussed in relation to the literature, which suggests both immunoregulatory and inhibitory effects on fibroblast growth. SOURCE: http://www.blackwell-synergy.com/doi...ournalCode=ced |
08-13-2007, 06:36 PM | #5 (permalink) |
Team TanTalk Join Date: Aug 12 2004 Location: ITA 2004-2013 / ASA 2013
Posts: 3,444
Rep Power: 30 | Re: Vitamin D for treatment of scleroderma Not speaking for Eileen but I assume she felt this was a topic that should have it's own thread in this forum. Someone else asked a question in another thread that sent Eileen on a search for what she posted here. |
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