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Old 07-06-2014, 07:16 PM   #1 (permalink)
Don Smith
 
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Location: Tucson, AZ
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Thumbs up Message: Avoid UVR Avoidance

Avoidance of sun exposure is a risk factor for all-cause mortality: results from the Melanoma in Southern Sweden cohort

P. G. Lindqvist1, E. Epstein2, M. Landin-Olsson3, C. Ingvar4, K. Nielsen5, M. Stenbeck6 & H. Olsson7
From the1Department of Obstetrics and Gynecology, Clintec, Karolinska University Hospital; 2Department of Obstetrics and Gynecology,Mothers and Children’s Health, Karolinska University Hospital, Stockholm; 3Department of Endocrinology, Clinical Science ; 4Department of Surgery, Clinical Science; 5Department of Dermatology, Helsingborg Hospital, Clinical Sciences, Lund University, Lund; 6Department of Clinical Neuroscience, Karolinska Institutet, Stockholm; and 7Department of Oncology and Cancer Epidemiology, Lund University Hospital, Lund, Sweden

Abstract. Avoidance of sun exposure is a risk factor for all-cause mortality: results from the MISS cohort. / Intern Med 2014; 276: 77–86.

Background. Sunlight exposure and fair skin are major determinants of human vitamin D production, but they are also risk factors for cutaneous malignant melanoma (MM). There is epidemiological
evidence that all-cause mortality is related to low vitamin D levels.

Methods. We assessed the avoidance of sun exposure as a risk factor for all-cause mortality for 29 518 Swedish women in a prospective 20-year follow-up of the Melanoma in Southern Sweden (MISS) cohort. Women were recruited from 1990 to 1992 and were aged 25 to 64 years at the start of the study. We obtained detailed information at baseline on their sun exposure habits and potential confounders. Multivariable flexible parametric survival analysis was applied to the data.

Results. There were 2545 deaths amongst the 29 518 women who responded to the initial questionnaire. We found that all-cause mortality was inversely related to sun exposure habits. The mortality rate amongst avoiders of sun exposure was approximately twofold higher compared with the highest sun exposure group, resulting in excess mortality with a population attributable risk of 3%.

Conclusion. The results of this study provide observational evidence that avoiding sun exposure is a risk factor for all-cause mortality. Following sun exposure advice that is very restrictive in countries with low solar intensity might in fact be harmful to women’s health.

Keywords: evolution, longevity, melanoma, population
attributable risk, UV radiation, vitamin D.

Some highlights of the study:

Use of sunbeds?
No = 1.0 (Baseline) / Yes = 0.77 (23% reduction in all cause mortality)

Sunbathing during winter holiday?
No = 1.0 (Baseline / Yes = 0.81 (19% reduction in all cause mortality)

Sunbathing during summer?
No = 1.0 (Baseline / Yes = 0.74 (26% reduction in all cause mortality)

Sunbathing during holiday abroad?
No = 1.0 (Baseline / Yes = 0.83 (17% reduction in all cause mortality)

All four of the above?
No = 1.0 (Baseline / Yes = 0.53 (47% reduction in all cause mortality)

More later.....
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