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skywalk · 10-08-2008, 03:09 PM

since we're cutting and pasting, I did a google search and cut the first link that popped up:

summary if you can't be bothered to read: you can increase blood circulation to the skin by applying something onto it, that causes vasodilation. This abstract merely tells you what's more effective in different areas of the body, for diabetics to increase circulation to the skin.

Titre du document / Document title

Topical methyl nicotinate-induced skin vasodilation in diabetic neuropathyAuteur(s) / Author(s)

CASELLI Antonella (1 2) ; HANANE Tarik (1) ; JANE Brady (1) ; CARTER Stephen (3) ; KHAODHIAR Lalita (1) ; VEVES Aristidis (1) ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Joslin-Beth Israel Deaconess Foot Center Department of Surgery, Microcirculation Laboratory, Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston, MA, ETATS-UNIS
(2) Department of Internal Medicine, University of Tor Vergata, Rome, ITALIE
(3) Biochemics Inc., Danvers, MA, ETATS-UNIS
Résumé / Abstract

Objective: To evaluate the vasodilation induced by topical application of methyl nicotinate (MN) and to compare it with the vasodilatory response to acetylcholine (ACh) and sodium nitroprusside (SNP) in healthy subjects and diabetic neuropathic patients. Research design and methods: Ten diabetic patients with peripheral neuropathy (DN) and 10 age- and sex-matched healthy control subjects (C) were enrolled. The vasodilatory response to topical application of 1% MN and a placebo emulsion at the forearm and dorsum of the foot skin at 5, 15, 30, 60 and 120 min was measured using Laser Doppler Perfusion Imaging. The vasodilatory response to iontophoresis of 1% ACh and 1% SNP solutions was also evaluated. Results: The maximal vasodilatory response to ACh, SNP and MN was similar at the forearm and foot level in the diabetic patients. In the control group, the responses to MN, ACh and SNP were similar on the forearm but in the foot, the MN vasodilatory response was higher when compared to the ACh and SNP responses. MN-related vasodilation was present 5 min after the application, reached its peak at 15-30 min and declined to pre-application levels 120 min afterward. Conclusions: Topical application of MN at the forearm and foot levels of diabetic neuropathic patients results in skin vasodilation that is comparable to the maximal vasodilation that can be induced by iontophoresis of ACh or SNP and lasts for less than 2 h. Further studies will be required to explore the potential of MN to increase blood flow and to prevent diabetic foot problems in clinical practice.Revue / Journal Title

Journal of diabetes and its complications ISSN 1056-8727 Source / Source

2003, vol. 17, no4, pp. 205-210 [6 page(s) (article)] (27 ref.)

10-08-2008, 03:09 PM	#4 (permalink)
skywalk Join Date: Mar 26 2004 Posts: 23 Rep Power: 0	Re: Looks like tinea but isn't since we're cutting and pasting, I did a google search and cut the first link that popped up: summary if you can't be bothered to read: you can increase blood circulation to the skin by applying something onto it, that causes vasodilation. This abstract merely tells you what's more effective in different areas of the body, for diabetics to increase circulation to the skin. Titre du document / Document title Topical methyl nicotinate-induced skin vasodilation in diabetic neuropathyAuteur(s) / Author(s) CASELLI Antonella (1 2) ; HANANE Tarik (1) ; JANE Brady (1) ; CARTER Stephen (3) ; KHAODHIAR Lalita (1) ; VEVES Aristidis (1) ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s) (1) Joslin-Beth Israel Deaconess Foot Center Department of Surgery, Microcirculation Laboratory, Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston, MA, ETATS-UNIS (2) Department of Internal Medicine, University of Tor Vergata, Rome, ITALIE (3) Biochemics Inc., Danvers, MA, ETATS-UNIS Résumé / Abstract Objective: To evaluate the vasodilation induced by topical application of methyl nicotinate (MN) and to compare it with the vasodilatory response to acetylcholine (ACh) and sodium nitroprusside (SNP) in healthy subjects and diabetic neuropathic patients. Research design and methods: Ten diabetic patients with peripheral neuropathy (DN) and 10 age- and sex-matched healthy control subjects (C) were enrolled. The vasodilatory response to topical application of 1% MN and a placebo emulsion at the forearm and dorsum of the foot skin at 5, 15, 30, 60 and 120 min was measured using Laser Doppler Perfusion Imaging. The vasodilatory response to iontophoresis of 1% ACh and 1% SNP solutions was also evaluated. Results: The maximal vasodilatory response to ACh, SNP and MN was similar at the forearm and foot level in the diabetic patients. In the control group, the responses to MN, ACh and SNP were similar on the forearm but in the foot, the MN vasodilatory response was higher when compared to the ACh and SNP responses. MN-related vasodilation was present 5 min after the application, reached its peak at 15-30 min and declined to pre-application levels 120 min afterward. Conclusions: Topical application of MN at the forearm and foot levels of diabetic neuropathic patients results in skin vasodilation that is comparable to the maximal vasodilation that can be induced by iontophoresis of ACh or SNP and lasts for less than 2 h. Further studies will be required to explore the potential of MN to increase blood flow and to prevent diabetic foot problems in clinical practice.Revue / Journal Title Journal of diabetes and its complications ISSN 1056-8727 Source / Source 2003, vol. 17, no4, pp. 205-210 [6 page(s) (article)] (27 ref.)