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Sheila in Minnesota · 01-11-2006, 05:35 PM

Melanoma Risk Only Partially Associated With Sun Exposure

NEW YORK (Reuters Health) Jan 02 - A decreased ability to repair DNA damage due to ultraviolet B (UV-B) exposure is a key player in the development of basal cell and squamous cell carcinoma, but not cutaneous malignant melanoma, research findings indicate.
In the study, Dr. Li-E Wang and colleagues from the University of Texas M. D. Anderson Cancer Center in Houston compared DNA repair activity after experimental UV-B exposure in white blood cells from 469 patients with melanoma or nonmelanoma skin cancers and 329 cancer-free patients.
The team discovered that the frequency of UV-B-induced chromatid breaks per cell was statistically significantly higher in nonmelanoma skin cancer (i.e., basal and squamous cell carcinoma) patients than in control subjects but was the same in cutaneous malignant melanoma and control subjects.
A higher number of chromatid breaks was associated with a more than twofold increased risk for nonmelanoma skin cancer but was not associated with risk of melanoma, Dr. Wang and colleagues report in the December 21st issue of the Journal of the National Cancer Institute.
The risk of nonmelanoma skin cancer associated with chromatid breaks increased with increased exposure to UV-B radiation.
There was also evidence that sensitivity to UV-B radiation may interact with other known risk factors, such as light hair and skin color, sunburn history, tanning ability, and freckling to increase the risk of nonmelanoma skin cancers but not melanoma.
"Our findings suggest that nonmelanoma skin cancer and cutaneous malignant melanoma have different etiologies in addition to UV exposure," Dr. Wang and colleagues note.
Specifically, the findings suggest to the team that UV-B-induced mutagen sensitivity reflects susceptibility to nonmelanoma skin cancer but not cutaneous malignant melanoma.
J Natl Cancer Inst 2005;97:1822-1831.

So..... read this.... share it with staff and clients ~ and hope that SOMEONE in mass media uses this info the next time Anti-Tan whips out there misguided bullsh*it about our services :)

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01-11-2006, 05:35 PM	#1 (permalink)
Sheila in Minnesota Join Date: Jan 3 2002 Location: USA Posts: 1,805 Rep Power: 7	Good News (that we already knew :) ) Melanoma Risk Only Partially Associated With Sun Exposure NEW YORK (Reuters Health) Jan 02 - A decreased ability to repair DNA damage due to ultraviolet B (UV-B) exposure is a key player in the development of basal cell and squamous cell carcinoma, *but not cutaneous malignant melanoma, research findings indicate.* In the study, Dr. Li-E Wang and colleagues from the University of Texas M. D. Anderson Cancer Center in Houston compared DNA repair activity after experimental UV-B exposure in white blood cells from 469 patients with melanoma or nonmelanoma skin cancers and 329 cancer-free patients. The team discovered that the frequency of UV-B-induced chromatid breaks per cell was statistically significantly higher in nonmelanoma skin cancer (i.e., basal and squamous cell carcinoma) patients than in control subjects but was the same in cutaneous malignant melanoma and control subjects. A higher number of chromatid breaks was associated with a more than twofold increased risk for nonmelanoma skin cancer but was not associated with risk of melanoma, Dr. Wang and colleagues report in the December 21st issue of the Journal of the National Cancer Institute. The risk of nonmelanoma skin cancer associated with chromatid breaks increased with increased exposure to UV-B radiation. There was also evidence that sensitivity to UV-B radiation may interact with other known risk factors, such as light hair and skin color, sunburn history, tanning ability, and freckling to increase the risk of nonmelanoma skin cancers but not melanoma. "Our findings suggest that nonmelanoma skin cancer and cutaneous malignant melanoma have different etiologies in addition to UV exposure," Dr. Wang and colleagues note. Specifically, the findings suggest to the team that UV-B-induced mutagen sensitivity reflects susceptibility to nonmelanoma skin cancer but not cutaneous malignant melanoma. J Natl Cancer Inst 2005;97:1822-1831. *So..... read this.... share it with staff and clients ~ and hope that SOMEONE in mass media uses this info the next time Anti-Tan whips out there misguided bullshit about our services :)** Related Links Resource Centers