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Old 11-20-2004, 11:19 AM   #8 (permalink)
Neon Beach
 
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Location: Ontario
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Benzoyl Peroxide and Premature Skin Aging: Benzoyl peroxide creates free radicals in the skin and is known to cause premature skin aging. Damage is determined by the concentration of benzoyl peroxide and the frequency of use. It has also been associated with increased risks of skin cancer (but then what isn't these days). In 1995 the FDA issued warnings regarding the use of benzoyl peroxide and changed its status from safe to uncertain.

Because BP generates free radicals it interferes with and slows the healing process. The red and brown marks that are a part of the acne healing process may last weeks longer when BP is a regular part of the daily regimen.

BP has been linked to cancer for a number of years and many research journal entries state "benzoyl peroxide is a free radical-generating skin tumor promoting agent." Performing a word search of the words "benzoyl peroxide cancer" in PubMed in the National Library of Medicine produces 102 articles from medical publications dealing with research aspects of BP and cancer. About two-thirds of the research supports linkage between BP and skin cancer.

"In 1995 the FDA changed benzoyl peroxide from a Category I (safe) to a Category III (safety is uncertain) ingredient and stated this action (56 FR 37622) was based on new information that raised a safety concern regarding benzoyl peroxide as a tumor promoter in mice..." Additionally the FDA charged manufacturers with the responsibility of providing this information to consumers so they could make educated decisions.

FDA / Benzoyl Peroxide Action: February 17, 1995
Food and Drug Administration (FDA) / Department of Health and Human Services
"Topical Drug Products Containing Benzoyl Peroxide: Required Labeling"
"The Food and Drug Administration (FDA) is proposing additional labeling (warning and directions) for all topically-applied acne treatment drug products containing benzoyl peroxide. The warning advises consumers to avoid unnecessary sun exposure and to use a sunscreen when using a benzoyl peroxide product to treat acne..."

"The agency classified benzoyl peroxide from its previous status Category I to Category III status. This action (56 FR 37622) was based on new information that raised a safety concern regarding benzoyl peroxide as a tumor promoter in mice and a study that reported that benzoyl peroxide has tumor initiation potential."

"FDA evaluated these data and information and determined that the studies show that benzoyl peroxide is a skin tumor promoter in more than one strain of mice as well as in hamsters. To date, topical studies (which have shown only tumor promotion) have been of short duration (about 52 weeks). Although animal data and human epidemiology data are available, the agency has determined that further studies are necessary to adequately assess the tumorigenic potential of benzoyl peroxide. These studies are currently being conducted. The agency acknowledges that it may take several years for these studies to be completed and analyzed, and for the final determination to be made on benzoyl peroxide's safety."
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